![[Pyr1]-Apelin-13](/ProductImageEN1/2024-11/Large/5880a1bf-636a-498f-954a-3e3c6b4a149c.png)
![[Pyr1]-Apelin-13](/ProductImageEN1/2024-11/Small/5880a1bf-636a-498f-954a-3e3c6b4a149c.png)
[Pyr1]-Apelin-13 NEW
| Price | $89 | $289 | $455 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: [Pyr1]-Apelin-13 | CAS No.: 217082-60-5 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | [Pyr1]-Apelin-13 |
| Description | [Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist. |
| In vitro | Encapsulation of [Pyr1]-apelin-13 in lipoPEG particles (lipoPEG-PA13) enables sustained and extended drug release in both in vitro and in vivo conditions[1]. |
| In vivo | In a study involving a mouse model of pressure-overload induced heart failure, nanocarriers containing [Pyr1]-apelin-13 demonstrated a prolonged effect in preventing cardiac dysfunction, highlighting its potential therapeutic benefits. Additionally, [Pyr1] apelin-13 at doses of 1 and 5 μg was found to enhance locomotor activity, alleviate pain symptoms, decrease cavity size, and reduce caspase-3 levels in rats, indicating its analgesic and anti-inflammatory properties. Furthermore, the compound significantly increased thermal paw withdrawal latency and, at a 5 μg dose, notably improved paw withdrawal threshold in comparison to spinal cord injury (SCI) animals from the second week post-SCI, suggesting its effectiveness in pain management and functional recovery post-SCI. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 50 mg/mL (32.60 mM) |
| Keywords | [Pyr1]-Apelin-13 | Inhibitor | [Pyr-1]-Apelin-13 | [Pyr1] Apelin 13 | [Pyr1]Apelin13 | inhibit |
| Inhibitors Related | ELA-11 (human) acetate(1784687-32-6 free base) | Apelin-12 acetate | AM-8123 | Azelaprag | CMF019 |
| Related Compound Libraries | Bioactive Compound Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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