Product Details
| Product Name:
Protopine |
CAS No.:
130-86-9 |
| Purity:
99.45% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | Protopine |
| 描述 | Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic. |
| 激酶實(shí)驗(yàn) | HT1080 cells are seeded in 24-well plates (2×104 cells per well) and treated with Dorsomorphin in the presence or absence of glucose or 10 mM 2DG for 2 h. HT1080 cells that overexpressed the wild-type and dominant negative AMPKα1 are prepared by transfecting plasmid DNA (pAMPKα1-wt, pAMPKα1-D168A and pcFlag as a control) in 6-well plates, seeding in 24-well plate and treating with UPR inhibitors. Cells are lysed with cell lysis buffer (20 mM Tris-HCl, pH 7.5, 250 mM NaCl, 10% glycerol, 0.5% NP-40, 1 mM EDTA, 1 mM EGTA, 0.2 mM PMSF, 1 μg/mL pepstatin, 0.5 μg/mL leupeptin, 5 mM NaF, 2 mM Na3Vo4, 2 mM β-glycerophosphate, 1 mM DTT). Relative AMPK kinase activity (mean±SD of duplicate determinations) to control sample (vehicle or pcFlag under normal growth conditions) is determined using the CycLex AMPK kinase assay kit[2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 3.53 mg/mL (10 mM), Sonication is recommended.
Chloroform 1:15 : Soluble
|
| 關(guān)鍵字 | Reactive Oxygen Species | Inhibitor | inhibit | Protopine |
| 相關(guān)產(chǎn)品 | Sodium Thiocyanate | Imeglimin hydrochloride | Meclizine dihydrochloride | L-Ascorbic acid | α-Vitamin E | Famotidine | Glucosamine | D-(+)-Glucono-1,5-lactone | Lycopene | Coenzyme Q10 | Naringenin | Alginic acid |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 疼痛相關(guān)化合物庫(kù) | 中藥單體化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 中藥抗炎分子庫(kù) | 天然產(chǎn)物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗衰老化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) | 藥食同源庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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