Protein kinase D inhibitor 1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: Protein kinase D inhibitor 1 | CAS No.: 2489320-03-6 |
| Supply Ability: 10g | Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | Protein kinase D inhibitor 1 |
| Description | Protein kinase D inhibitor 1 (compound 17m) is a potent pan-PKD inhibitor with IC50 values between 17 and 35 nM, demonstrating inhibitory activity in the low nanomolar range. By inhibiting protein kinase D, it effectively suppresses PKD-dependent cortactin phosphorylation [1]. |
| In vitro | Protein kinase D inhibitor 1 (compound 17m) exhibits potent inhibition of PKD2 with almost no kinase activity at 1 μM [1]. Despite its significant PKD2 inhibition, it shows minimal antiproliferative effects on PANC-1 cells at 5 μM [1]. However, it reveals antitumor activity across a range of concentrations (0-100 μM) over 72 hours [1]. In a Cell Viability Assay on various cell lines including LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, and K-562, this compound effectively inhibited tumor cell growth. The IC50 values were 80.6 ± 7, 40.7 ± 14.5, 42.7 ± 4.9, 17.9 ± 4.1, and 35.3 ± 10.4 for the first five lines respectively, while exceeding 95.8 μM for NCI-H460, and greater than 100 μM for both HCT-116 and K-562 [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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