Prostaglandin E2 NEW
| Price | $35 | $35 | $48 | $48 | $68 | $68 |
| Package | 1mg | 1mg | 2mg | 2mg | 5mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Prostaglandin E2 | CAS No.: 363-24-6 |
| Purity: 99.95% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Prostaglandin E2 |
| 描述 | Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in various physiological processes, such as smooth muscle contraction and relaxation, vasodilation and constriction, blood pressure regulation, and inflammatory regulation. |
| 體外活性 | METHODS: Human colorectal cancer cells LS-174T were treated with Prostaglandin E2 (0.05-10 μM) for 1-60 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Prostaglandin E2 induced phosphorylation of Akt as early as 1 min after stimulation, and the activation of Akt reached a maximum within 10 min and persisted until 60 min. The addition of Prostaglandin E2 activated Akt in a dose-dependent manner. [1] METHODS: FDC-like cells were treated with Prostaglandin E2 (1 μM) for 15-120 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Prostaglandin E2 did not increase p-ERK, but decreased p-ERK at 60 and 120 min. on the contrary, p-p38 increased starting at 15 min and continued to 60 min. [2] |
| 體內(nèi)活性 | METHODS: To test the role of EP2 receptors in the in vivo absorption response, Prostaglandin E2 (3 mg/kg) was injected subcutaneously four times daily for three days into EP2+/+ and EP2-/- mice on a 129/SvEv background. RESULTS: Prostaglandin E2 increased serum calcium from 9.8+/-0.5 to 10.7+/-0.3 mg/dL in EP2+/+ mice but not in EP2-/- mice. [3] METHODS: To study the effects on bone, Prostaglandin E2 (6 mg/kg) was injected subcutaneously into C57BL/6 mice once daily for 3-12 days. RESULTS: Prostaglandin E2-treated mice showed a decrease in trabecular bone volume (BV/TV) at 14 days, indicating increased bone resorption. However, the Prostaglandin E2-treated 3-day group also stimulated bone formation at 14 days due to increased mineral deposition rate (MAR) and bone formation rate (BFR/BS). [4] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (141.86 mM) 5% DMSO+95% Saline : 1.5 mg/mL (4.26 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| 關鍵字 | Prostaglandin E-2 | inhibit | Endogenous Metabolite | Prostaglandin Receptor | Prostaglandin E 2 | Inhibitor | PGE-2 | Prostaglandin E2 | PGE 2 |
| 相關產(chǎn)品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相關庫 | 抗癌天然產(chǎn)物庫 | 疼痛相關化合物庫 | 膜蛋白靶向化合物庫 | 抗癌上市藥物庫 | 高通量篩選天然產(chǎn)物庫 | 人內(nèi)源代謝化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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