Product Details
| Product Name:
PQM130 |
CAS No.:
2089415-51-8 |
| Purity:
99.31% |
Supply Ability:
10g |
| Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | PQM130 |
| 描述 | PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies. |
| 體外活性 | PQM130 had already shown anti-inflammatory activity in different in vivo models and neuroprotective activity in human neuronal cells. |
| 體內(nèi)活性 | The intracerebroventricular (i.c.v.) injection of AβO in mice caused the increase of memory impairment, oxidative stress, neurodegeneration, and neuroinflammation.?Instead, PQM130 (0.5-1 mg/kg) treatment after the i.c.v. AβO injection reduced oxidative damage and neuroinflammation and induced cell survival and protein synthesis through the modulation of glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinases (ERK1/2).?Moreover, PQM130 increased brain plasticity and protected mice against the decline in spatial cognition.?PQM130 modulated different pathways compared to donepezil, and it is much more effective in counteracting AβO damage. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5.5 mg/mL (14.42 mM)
|
| 關(guān)鍵字 | Inhibitor | PQM130 | Amyloid-β | β-amyloid peptide | Abeta | PQM 130 | PQM-130 | inhibit |
| 相關(guān)產(chǎn)品 | Anle138b | BSBM7 | Notoginsenoside R1 | Geniposide | Deferoxamine Mesylate | Tramiprosate | Dihydroergocristine mesylate | Rutin | Ginsenoside Rg2 | Methyl tridecanoate | Ginsenoside Re | DAPT |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 神經(jīng)信號(hào)分子庫(kù) | 神經(jīng)保護(hù)化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$39.00/5mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-12 |
United States