Polyinosinic-polycytidylic acid sodium NEW
| Price | $38 | Get Latest Price | $88 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Polyinosinic-polycytidylic acid sodium | CAS No.: 42424-50-0 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Polyinosinic-polycytidylic acid sodium |
| Description | Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). |
| In vitro | Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5). The effect of polyi:c on tumor immunotherapy has been well explored for several decades. The accumulated evidence suggests that polyi:c could be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells[2]. |
| In vivo | Polyinosinic-polycytidylic acid significantly inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells, resulting in a 50% reduction in human DNA levels in treated mice[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble） H2O : 10 mg/mL, Sonication and heating are recommended. |
| Keywords | proper | dsRNA | Apoptosis | Poly(I:C) | TLR3 | immunotherapy | double-stranded | inhibit | tumor | microenvironment | Polyinosinic-polycytidylic acid | RNA | Toll-like Receptor (TLR) | RIG-I | MDA5 | Polyinosinicpolycytidylic acid sodium | Inhibitor | Polyinosinic-polycytidylic acid sodium | annealing | Polyinosinic polycytidylic acid sodium |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Hydroxychloroquine | Metronidazole | Sorafenib | Tributyrin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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