Polygalasaponin F NEW
| Price | $100 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Polygalasaponin F | CAS No.: 882664-74-6 |
| Purity: 99.83% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Polygalasaponin F |
| 描述 | Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (54.98 mM) |
| 關鍵字 | Phosphoinositide 3-kinase | Nuclear factor-kappaB | inhibit | PI3K | Protein kinase B | PKB | Polygalasaponin F | Nuclear factor-κB | NF-κB | Toll-like Receptor (TLR) | Akt | Inhibitor |
| 相關產(chǎn)品 | Myricetin | Hydroxychloroquine | Diethylmaleate | Chloroquine phosphate | Glucosamine | Lidocaine hydrochloride | Chloranil | Indole-3-carbinol | Diallyl disulfide | 2,3-Butanediol |
| 相關庫 | 抗癌天然產(chǎn)物庫 | 萜類天然產(chǎn)物庫 | 中藥單體化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 中藥抗炎分子庫 | 高通量篩選天然產(chǎn)物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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