Pioglitazone NEW
| Price | $35 | $48 | $63 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Pioglitazone | CAS No.: 111025-46-8 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Pioglitazone |
| Description | Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione indicated for the treatment of type 2 diabetes, and has been linked to rare instances of acute liver injury. |
| In vitro | In mouse models of Parkinson's disease (PD) using MPTP, Pioglitazone reduces activation of microglia, inducible nitric oxide synthase (iNOS) positive cells, and glial fibrillary acidic protein (GFAP) positive cells in the striatum and substantia nigra pars compacta. Administering approximately 20 mg/kg of Pioglitazone daily attenuates MPTP-induced neuroglial activation and prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Additionally, in 10-month-old APPV717I transgenic mice, Pioglitazone decreases the number of activated microglia and reactive astrocytes in the hippocampus and cortex. Pioglitazone also reduces mRNA and protein levels of beta-secretase-1 (BACE1), as well as the levels of soluble Abeta1-42 peptide. |
| In vivo | Pioglitazone is primarily metabolized by CYP2C8, with secondary metabolism by CYP3A4. |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 13.33 mg/mL (37.41 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Peroxisome proliferator-activated receptors | diabete | domain | PPARγ | inhibit | Ferroptosis | U72107 | PPAR | blood glucose | ligand-binding | Inhibitor | Pioglitazone | U-72107 |
| Inhibitors Related | TBHQ | Acetylcysteine | α-Vitamin E | Daidzein | Sorafenib | Curcumin | L-Cystine | L-Glutamic acid monosodium salt | Naringenin | 2,3-Butanediol |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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