![Philanthotoxin 74 dihydrochloride](/ProductImageEN1/2024-11/Large/7e609c19-43fb-44a5-98e3-909fa493d336.png)
Philanthotoxin 74 dihydrochloride NEW
Price | $47 | $149 | Get Latest Price |
Package | 1mg | 5mg | 50mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: Philanthotoxin 74 dihydrochloride | CAS No.: 1227301-51-0 |
Purity: 98.6% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | Philanthotoxin 74 dihydrochloride |
Description | Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1. |
In vitro | Philanthotoxin 74 dihydrochloride inhibits the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3 in the micromolar concentration range, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 dihydrochloride (500 μM) fully inhibits GluA1/A2R receptors and produces 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74 dihydrochloride (100 and 500 μM) displays a pronounced channel block (> 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Philanthotoxin 74 dihydrochloride inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1]. |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 90 mg/mL (177.33 mM), Sonication is recommended. H2O : 40 mg/mL (78.81 mM), Sonication is recommended. |
Keywords | PhTx 74 | Philanthotoxin 74 Dihydrochloride | Philanthotoxin 74 | PhTx 74 Dihydrochloride |
Inhibitors Related | Mephenesin | Decanoic Acid | L-Glutamic acid | glycine | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | D-Cycloserine | Piracetam | Linalool | O-Phospho-L-serine |
Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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