Phe-Met-Arg-Phe, amide acetate NEW
| Price | $46 | $64 | $91 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Phe-Met-Arg-Phe, amide acetate | Purity: 99.4% |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Phe-Met-Arg-Phe, amide acetate |
| Description | Phe-Met-Arg-Phe, amide acetate, activates a K+ current in peptidergic caudodorsal neurons dose-dependently (ED50=23 nM) and appears to localize with neuropeptide Y in some brain regions. |
| In vitro | In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurons and activates a novel K+ current characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors necessary for channel opening[1]. At 1 μM, it significantly inhibits glucose-stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) has no effect on glucagon secretion, whether in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2]. |
| In vivo | Phe-Met-Arg-Phe amide (FMRFamide) has been identified to stimulate growth hormone secretion in conscious ovariectomized (OVX) rats. Its immunoreactivity within hypothalamic neuronal elements hints at its involvement in regulating anterior pituitary functions. Administration of 200 ng (313.8 picomoles) of FMRFamide in a 2 uL volume significantly elevates plasma growth hormone (GH) levels within 15 minutes post-injection. Moreover, a dose range of 400-800 ng (627-1255 picomoles) of FMRFamide induces a rapid increase in GH levels, observable as early as 5 minutes and persisting for up to 30 minutes. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mM |
| Keywords | 64190-70-1 freebase | Phe Met Arg Phe, amide acetate | PheMetArgPhe, amide acetate | Phe-Met-Arg-Phe, amide Acetate |
| Inhibitors Related | Minoxidil sulfate | Glibenclamide | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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