PF-2771 NEW
| Price | $1490 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-20 |
Product Details
| Product Name: PF-2771 | CAS No.: 2070009-55-9 |
| Supply Ability: 10g | Release date: 2024/11/20 |
Product Introduction
Bioactivity
| Name | PF-2771 |
| Description | PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor with an IC50 of 16.1 nM, used as an anticancer agent. |
| In vitro | PF-2771 is a powerful and selective inhibitor of CENP-E, demonstrating significant inhibition of CENP-E motor activity at an IC50 of 16.1 nM, without affecting ATPase activities of similar kinesins (showing 0% inhibition of Eg5/KSP, chromokinesin, and MCAK at both 1 or 10 μM concentrations). It also displays negligible inhibitory effects on 74 protein kinases (less than 23% inhibition at 1 μM and less than 40% at 10 μM). Notably, PF-2771 is cytotoxic exclusively to basal-like breast cancer cells, with EC50 values below 0.1 μM, while it has no cytotoxic effects on normal and premalignant cell lines (EC50 > 5 μM). Furthermore, at 100 nM, PF-2771 induces a chromosomal congression defect in MDA-MB-468 cells. |
| In vivo | PF-2771 (100 mg/kg, daily i.p.) effectively inhibits CENP-E motor function, resulting in tumor regression in SCID mice with AA1077 mammary tumors [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 32 mg/mL (57.75 mM) |
| Keywords | PF 2771 | PF2771 | PF-2771 |
| Inhibitors Related | Eg5-IN-1 | Eg5 Inhibitor V, trans-24 | AZD-4877 | UMK57 | BAY1217389 | BRD9876 | Paprotrain | SB-743921 hydrochloride | S-trityl-L-Cysteine | Empesertib | MPI-0479605 | CW-069 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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