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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Metabolism>Transferase Inhibitors>PF-04620110
PF-04620110
  • PF-04620110

PF-04620110 NEW

Price $37 $57 $106
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PF-04620110 CAS No.: 1109276-89-2
Purity: 99.82% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePF-04620110
DescriptionPF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
In vitroAmpiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2]
In vivoIn Rats, PF-04620110 reduces plasma triglyceride levels t doses of ≥0.1 mg/kg following a lipid challenge. [1] DGAT1 inhibition by PF-04620110 causes an enrichment of polyunsaturated fatty acids within the TG class of lipids in rodents. [2]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 19.8 mg/mL (50 mM), Sonication and heating are recommended.
Keywordsacyl-CoA:cholesterol acyltransferase | mono- acylglycerol acyltransferase | Diacylglycerol acyltransferase | Diglyceride acyltransferase | Acyltransferase | Inhibitor | PF-04620110 | inhibit
Inhibitors RelatedSerotonin hydrochloride | Risedronate Sodium | Cyclandelate | Risedronic Acid | YM17E | 3-Methoxybenzamide | Entacapone | 2-Furoic acid | OU749 | Ibandronate sodium | Alendronate sodium hydrate | Flopropione
Related Compound LibrariesBioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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