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Postion:Product Catalog >PD 90780
PD 90780
  • PD 90780

PD 90780 NEW

Price $51 $122 $197
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-12

Product Details

Product Name: PD 90780 CAS No.: 77422-99-2
Purity: 98.75% Supply Ability: 10g
Release date: 2024/11/12

Product Introduction

Bioactivity

名稱PD 90780
描述PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
體外活性PD 90780 (0.1-100 μM; 2 h) impacts 125I-BDNF binding to truncated p75NTR, and at 100 μM, it inhibits 125I-NGF cross-linking to p75NTR. At concentrations of 0-300 μM, PD 90780 decreases TrkA phosphorylation resulting from NGF binding, with significant inhibition noted at 300 μM. Additionally, PD 90780 (0.1-100 μM; 2 h) inhibits the NGF-p75NTR interaction with IC50 values of 23.1 μM in PC12 cells and 1.8 μM in PC12nnr5 cells[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 28.8 mg/mL (79.5 mM), Sonication and heating to 60℃ are recommended.
關(guān)鍵字PD-90780 | PD 90780 | PD90780
相關(guān)庫經(jīng)典已知活性庫 | PPI抑制劑庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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