PD 169316
Price | Get Latest Price | ||
Package | 1g | 5g | 10g |
Min. Order: | 1g |
Supply Ability: | 1000 |
Update Time: | 2025-01-10 |
Product Details
Product Name: PD 169316 | CAS No.: 152121-53-4 |
Min. Order: 1g | Purity: 98 |
Supply Ability: 1000 | Release date: 2025/01/10 |
Product Name: PD 169316
Synonyms: PD 169316, >97%;CS-497;PD 169316 - CAS 152121-53-4 - Calbiochem;4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine;Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-5-yl]-;PD169316/PD-169316;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine PD 169316
CAS: 152121-53-4
MF: C20H13FN4O2
MW: 360.34
EINECS: 200-256-5
Product Categories: Inhibitors;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators
p38 is a member of the mitogen-activated protein kinase (MAPK) superfamily of enzymes that play an important role in signal transduction. PD 169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM, whereas the IC50s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα. PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.
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