Product Details
Product Name:
PCNA-I1 |
CAS No.:
444930-42-1 |
Purity:
97.64% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | PCNA-I1 |
Description | PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer. |
In vitro | PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin.?PCNA-I1 also induced autophagy in PC-3 cells.?A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.[1] |
In vivo | Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 3.1 mg/mL (10 mM), Sonication is recommended.
|
Keywords | PCNA-I-1 | DNA/RNA Synthesis | inhibit | PCNAI1 | Inhibitor | PCNA I1 | PCNA-I1 |
Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$1980.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |