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Postion:Product Catalog >PBRM1-BD2-IN-2
PBRM1-BD2-IN-2
  • PBRM1-BD2-IN-2

PBRM1-BD2-IN-2 NEW

Price $117 $268 $395
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: PBRM1-BD2-IN-2 CAS No.: 2819989-57-4
Purity: 100% Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱PBRM1-BD2-IN-2
描述PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. This compound is utilized in cancer research.
體外活性PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibits the growth of a PBRM1-dependent prostate cancer cell line. It exhibits binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B, and SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM, and 69 μM, respectively, and inhibits PBRM1-BD2 with an IC50 of 1.0 μM[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 45 mg/mL (144.63 mM)
關(guān)鍵字PBRM1-BD2-IN-2 | PBRM1BD2IN2
相關(guān)產(chǎn)品ABBV-744 | CeMMEC1 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | J-147 | Anacardic Acid | Curcumin | dBET6 | Piflufolastat | Naphthol AS-E | Bisdemethoxycurcumin | GSK1379725A
相關(guān)庫組蛋白修飾化合物庫 | 經(jīng)典已知活性庫 | 表觀遺傳庫 | 抑制劑庫 | PPI抑制劑庫 | 已知活性化合物庫 | 含氟化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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