Paraxanthine NEW
| Price | $57 | $85 | $121 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Paraxanthine | CAS No.: 611-59-6 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Paraxanthine |
| 描述 | Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector. |
| 體外活性 | Upon prolonged exposure to Paraxanthine (PX), there is a dose-dependent increase in the count of TH+ neurons within cultures, with the effect becoming significant at concentrations starting from 100 μM and reaching an optimum between 800 and 1000 μM at 10 days in vitro (DIV). This suggests that Paraxanthine likely contributes to the prevention of dopaminergic (DA) neuron loss. Comparatively, Glial cell line-derived neurotrophic factor (GDNF), a prime growth factor for DA neurons, exhibits only a marginally stronger efficacy than 800 μM of Paraxanthine in DA neuron rescue after 10 and 16 DIV, at its optimal concentration of 20 ng/mL. Notably, Paraxanthine, which is formed through N3-demethylation of approximately 80% of caffeine, is significantly more effective than caffeine in promoting DA neuron survival. For instance, while 800 μM of caffeine results in a modest 40% increase in TH+ neuron count at 10 DIV, an identical concentration of Paraxanthine achieves an optimal enhancement in DA cell survival, indicated by a 169% increase. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 1 mg/mL DMSO : 5.5 mg/mL (30.53 mM), Sonication is recommended. |
| 關鍵字 | inhibit | Inhibitor | Endogenous Metabolite | Paraxanthine |
| 相關產品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相關庫 | 經典已知活性庫 | 天然產物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 高通量篩選天然產物庫 | Ro5類藥天然產物庫 | 人內源代謝化合物庫 | 人內源代謝化合物庫 Plus | 已知活性化合物庫 | 腸道微生物代謝化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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