Osthole NEW
| Price | $31 | $65 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Osthole | CAS No.: 484-12-8 |
| Purity: 99.96% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Osthole |
| Description | Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation. |
| Cell Research | Osthole is dissolved in 96% ethyl alcohol and then sterilized through a 0.22 μg/mL filter and stored at 4°C as stock solutions for later dilution[1]. Peripheral blood samples are collected from participants between 7.00 and 9.00 a.m. on the first study day and these are concentrated in grouping tubes with K3EDTA. Fresh PBMCs are then prepared. Isolated cells are seeded on 24-well plates at 1×106 per well with RPMI-1640 and supplemented with 1% heat inactivated human AB serum, 1% gentamicin and 0.25% PHA. Active reagents are added to each well after 24 h and pure medium formed the control for each substance. Cells are then harvested after a further three days[1]. |
| In vitro | The LD50 values of Osthole in various animals have been determined as follows: in rats, it exceeds 125 mg/kg when administered intravenously (i.v.); in rabbits, it is over 35 mg/kg (i.v.); and in dogs, it surpasses 150 mg/kg (i.v.). |
| In vivo | Osthol, when introduced to pre-washed rabbit platelets, inhibits platelet aggregation and ATP release induced by ADP, arachidonic acid, platelet-activating factor (PAF), collagen, ionophore A23187, and thrombin. In human osteoblasts, osthol promotes cell differentiation through the bone morphogenetic protein-2 / p38 and extracellular signal-regulated kinase 1/2 pathways. Additionally, in cell cultures, osthol suppresses the secretion of the hepatitis B virus by enhancing the glycosylation of HBsAg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 46 mg/mL (188.3 mM) DMSO : 55 mg/mL (225.14 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | inhibit | Parasite | Inhibitor | Apoptosis | Osthole | Hepatitis B virus | NSC-31868 | NSC31868 | Histamine Receptor | HBV |
| Related Compound Libraries | Anti-Parasitic Compound Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Viral Compound Library | Antiparasitic Natural Product Library | Natural Product Library for HTS | Anti-virus Traditional Chinese Medicine Monomer Library | Bioactive Compounds Library Max | GPCR Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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