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Postion:Product Catalog >ONO-7475
ONO-7475
  • ONO-7475

ONO-7475 NEW

Price $57 $139 $222
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-13

Product Details

Product Name: ONO-7475 CAS No.: 1646839-59-9
Purity: 98.74% Supply Ability: 10g
Release date: 2024/11/13

Product Introduction

Bioactivity

名稱ONO-7475
描述ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
細胞實驗Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours[1].
體外活性ONO-7475 sensitized AXL-overexpressing?EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells[2].
體內活性Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells?in vitro?and?in vivo?by mechanisms that involve disruption of diverse survival and proliferation pathways[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (177.76 mM)
關鍵字lung | tumor | leukemia | inhibit | solid | ONO7475 | Trk Receptor | tolerant | cancer | Mer | Tropomyosin related kinase receptor | NSCLC | TAM Receptor | EGFR | ONO-7475 | ONO 7475 | Tyro3 | advanced | mutunt | Inhibitor | Axl | TKI | acute | metastatic
相關產品UNC2025 | Gilteritinib | Bemcentinib | Larotrectinib sulfate | N-Acetyl-5-hydroxytryptamine | Selitrectinib | SP600125 | Amitriptyline hydrochloride | 7,8-Dihydroxyflavone | Diosmetin | GW 441756 | Cabozantinib S-malate
相關庫經典已知活性庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 酪氨酸激酶分子庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌活性化合物庫 | 抗癌藥物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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