Olaparib
Price | $100 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 1t |
Update Time: | 2024-07-01 |
Product Details
Product Name: Olaparib | CAS No.: 763113-22-0 |
Min. Order: 1kg | Purity: 99% |
Supply Ability: 1t | Release date: 2024/07/01 |
Olaparib is a PARP inhibitor that also acts on BRCA1 or BRCA2 mutations. Olaparib has little effect on anchor-1, and IC50 value is greater than that of OLaparib. The concentration of Olaparib at 30-100 nM acts on SW620 cells and inactivates PARP-1. Compared with BRCA1 and BRCA2-sufficient cell lines (Hs578T,MDA-MB-231,T47D), BRCA1-deficient cell lines (MDA-MB-463 [2] and HCC1937) were over-sensitive to Olaparib, which inhibited PARP and blocked base excisation repair. Resulting in strong sensitivity of KB2P cells to Olaparib. The result is a shift from a single strand break to a double strand break during DNA replication, thus activating the BRCA2-dependent recombination pathway.
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- Since: 2015-08-19
- Address: Gate 6, Road 1, Liangxiang Industrial Park, Zhangdian District, Zibo City, Shandong China
13864437655
ziboweibinmaoyi@163.com