ODM-201
Price | $40 | $38 | $35 |
Package | 1Gram | 100Gram | 10000Gram |
Min. Order: | 1Gram |
Supply Ability: | 50Tons |
Update Time: | 2024-10-24 |
Product Details
Product Name: ODM-201 | CAS No.: 1297538-32-9 |
Min. Order: 1Gram | Purity: 99.99% |
Supply Ability: 50Tons | Release date: 2024/10/24 |
ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.
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- Since: 2021-05-08
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