OAC1 NEW
| Price | $31 | $42 | $64 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: OAC1 | CAS No.: 300586-90-7 |
| Purity: 99.65% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | OAC1 |
| 描述 | OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process. |
| 細胞實驗 | The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.(Only for Reference) |
| 激酶實驗 | Enzymology: Kinesin motor domains are expressed in Escherichia coli BL21(DE3) and purified. CENP-E proteins includes residues 2–340 with a carboxyl-terminal 6-his tag. All studies using MT are conducted in PEM25 buffer [25 mM PipesK+ (pH 6.8), 2 mM MgCl2, 1 mM EGTA] supplemented with 10 μM paclitaxel. The IC50 for steady-state inhibition is determined at 500 μM ATP, 5 μM MT, and 1 nM CENP-E in PEM25 buffer. |
| 體內(nèi)活性 | OAC1 appears to enhance reprogramming efficiency by increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 does not inhibit the p53-p21 pathway or activate Wnt-β-catenin signaling.OAC1 can be used to enhance the reprogramming of somatic cells to a pluripotent state.1 μM OAC1 enhances the reprogramming efficiency by activating the Oct4 and Nanog promoter-driven luciferase reporter genes. In addition, OAC1 enhanced the reprogramming efficiency and accelerated the reprogramming process of pluripotent stem cells (iPSCs) in mouse embryonic fibroblasts (MEFs) treated with four reprogramming factors (Oct4, Sox2, c-Myc and Klf4). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 23.7 mg/mL (100 mM) DMSO : 23.7 mg/mL (100 mM) |
| 關(guān)鍵字 | OAC1 | inhibit | induced pluripotent stem cells | HOXB4 | Slc22a3 | POU5F1 | Oct3/4 | Inhibitor | human IMR90 fibroblast cells | OAC 1 | BAS00287861 | BAS-00287861 | CD34+cells | Nanog promoters | OAC-1 | reprogramming |
| 相關(guān)產(chǎn)品 | O4I1 | OAC2 | Oct3/4-inducer-1 | O4I2 | 3-O-Methylgallic acid | Retrorsine | Jatrorrhizine chloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 干細胞分化化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌化合物庫 | 轉(zhuǎn)錄因子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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