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Postion:Product Catalog >NVR 3-778
NVR 3-778
  • NVR 3-778

NVR 3-778 NEW

Price $51 $122 $189
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-16

Product Details

Product Name: NVR 3-778 CAS No.: 1445790-55-5
Purity: 99.74% Supply Ability: 10g
Release date: 2024/11/16

Product Introduction

Bioactivity

名稱NVR 3-778
描述NVR 3-778 is a first-in-class, orally bioavailable HBV CAM belonging to the SBA class, exhibiting anti-HBV activity.
體外活性NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral (EC50: 0.40?μM in HepG2.2.15 cells). NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles. NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81?μM against HBV DNA and between 3.7μM and 4.8?μM against the production of HBV antigens and intracellular HBV RNA. NVR 3-778 targets HBV core protein and inhibits viral replication. NVR 3-778 has pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively.
體內(nèi)活性In dogs following oral administration, NVR 3-778 (1.5?mg/kg; i.g.) shows the mean Cmax and AUC0–inf values of 0.56?μg/ml and 3.50?μg·h/ml, respectively. And the mean oral bioavailability is determined to be 84.6%.
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 60 mg/mL (138.76 mM)
關鍵字NVR 3-778 | HBV | virus | assembly | CAM | modulator | inhibit | NVR 3 778 | capsid | Hepatitis | chronic | Hepatitis B virus | Inhibitor | NVR 3778
相關產(chǎn)品Doxorubicin hydrochloride | Osthole | RO8191 | Cetylpyridinium Chloride | Tenofovir Disoproxil Fumarate | Thiamine hydrochloride | 4,5-Dicaffeoylquinic acid | Vebicorvir | 4-Hydroxyacetophenone | Telbivudine | Tenofovir | Bifendate
相關庫經(jīng)典已知活性庫 | ReFRAME 相關化合物庫 | 藥物功能重定位化合物庫 | 抗病毒庫 | NO PAINS 化合物庫 | 口服活性化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 抗感染化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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