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Postion:Product Catalog >NU6140
NU6140
  • NU6140

NU6140 NEW

Price $58 $98 $197
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: NU6140 CAS No.: 444723-13-1
Purity: 98.33% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱NU6140
描述NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
體外活性NU6140 enhances catalytic activity of capase-9 and capase-3, causes an increase in the sub-G1 apoptotic cell population. NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H (IC50s: 6.6, 5.5, 15 and 3.9 μM, respectively)[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 250 mg/mL (591.69 mM), Sonication is recommended.
關(guān)鍵字CDK | Inhibitor | Aurora Kinase | inhibit | NU 6140 | NU6140 | NU-6140 | Cyclin dependent kinase
相關(guān)產(chǎn)品Ribociclib | Palmatine chloride | Ro-3306 | Palbociclib monohydrochloride | Palmatine | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Abemaciclib | Dinaciclib | Abemaciclib methanesulfonate
相關(guān)庫抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抑制劑庫 | 抗前列腺癌化合物庫 | NO PAINS 化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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