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Postion:Product Catalog >NMS-P715
NMS-P715
  • NMS-P715

NMS-P715 NEW

Price $72 $98 $155
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: NMS-P715 CAS No.: 1202055-32-0
Purity: 98.41% Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱NMS-P715
描述NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
體外活性NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1].
體內(nèi)活性NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 2 mg/mL (2.96 mM), Sonication is recommended.
關(guān)鍵字NMS-P 715 | Monopolar spindle 1 | Mps1 | NMS P715 | NMS-P-715 | inhibit | NMSP715 | Inhibitor | NMS-P715
相關(guān)產(chǎn)品Sodium lauryl sulfoacetate | TBCA | Vemurafenib | Ellagic acid | CMPD1 | SKLB-163 | Emodin | sodium lauroyl-α-hydroxyethyl sulfonate | LY-364947 | Takinib | NG25 | LY294002
相關(guān)庫抗結(jié)直腸癌化合物庫 | 成骨分子庫 | PI3K/Akt/mTOR 化合物庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 激酶抑制劑庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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