Nirmatrelvir NEW
| Price | $53 | $75 | $123 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Nirmatrelvir | CAS No.: 2628280-40-8 |
| Purity: 99.51% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Nirmatrelvir |
| Description | PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) . |
| In vitro | PF-07321332 is a promising oral antiviral clinical candidate with well-established anti-SARS-CoV-2 activity in vitro. |
| In vivo | METHODS: To assay in vivo antiviral activity, Nirmatrelvir (20 mg/kg, 2% DMSO + 20% sulfobutylether-β-cyclodextrin in 0.9% saline) and Molnupiravir (20 mg/kg) were orally administered to SARS-CoV-2 infected K18-hACE2 transgenic mice twice daily for five days. RESULTS: In lethally infected mice, the combination of Nirmatrelvir and Molnupiravir demonstrated severe inhibition of SARS-CoV-2 replication in the lungs and brain and synergistically improved survival by up to 80%. 36% survival was achieved with Nirmatrelvir alone, and 43% with Molnupiravir alone. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (90.08 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 13 mg/mL (26.02 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| Keywords | PF 07321332 | inhibit | Antiviral | virus | Inhibitor | PF07321332 | PF-07321332 | Nirmatrelvir | SARS coronavirus | HIV | SARS-CoV | 3CLPRO |
| Inhibitors Related | Hydroxychloroquine | Chloroquine phosphate |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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