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Postion:Product Catalog >API>Vitamins and Minerals medicines>Vitamin B drugs>Nicotinic acid
Nicotinic acid
  • Nicotinic acid
  • Nicotinic acid

Nicotinic acid NEW

Price $6 $0.2
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: Nicotinic acid CAS No.: 59-67-6
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information


Names

NameNicotinic acid
SynonymMore Synonyms

 Nicotinic acid Biological Activity

DescriptionNiacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.Target: OthersNiacin (also known as vitamin B3 and nicotinic acid) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Not enough niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. Chronic Niacin deficiency leads to a disease called pellagra. The lack of niacin may also be observed in pandemic deficiency disease which is caused by a lack of five crucial vitamins: niacin,vitamin C, thiamin, vitamin D and vitamin A, and is usually found in areas of widespread poverty and malnutrition.Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to decrease the risk of cardiovascular events modestly in a number of controlled human trials. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to and are precursors of NAD and NADP in vivo.Nicotinic acid, nicotinamide, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD+ kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis.High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.
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Target

Human Endogenous Metabolite

References

[1]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61.

[2]. Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun;164(6):1188-200.

[3]. Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):209-15.

 Chemical & Physical Properties

Density1.473
Boiling Point292.5±13.0 °C at 760 mmHg
Melting Point234-238 oC
Molecular FormulaC6H5NO2
Molecular Weight123.11
Flash Point130.7±19.8 °C
PSA55.98000
LogP0.15
Vapour Pressure0.0±0.6 mmHg at 25°C
Index of Refraction1.571
Storage condition0-6°C
StabilityStable. Incompatible with strong oxidizing agents. May be light sensitive.
Water Solubility1-5 g/100 mL at 17 oC

 MSDS

Nicotinic acid MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • QT0525000

  • CHEMICAL NAME :

  • Nicotinic acid

  • CAS REGISTRY NUMBER :

  • 59-67-6

  • BEILSTEIN REFERENCE NO. :

  • 0109591

  • LAST UPDATED :

  • 199710

  • DATA ITEMS CITED :

  • 19

  • MOLECULAR FORMULA :

  • C6-H5-N-O2

  • MOLECULAR WEIGHT :

  • 123.12

  • WISWESSER LINE NOTATION :

  • T6NJ CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - man

  • DOSE/DURATION :

  • 2571 mg/kg/90D-I

  • TOXIC EFFECTS :

  • Blood - change in clotting factors Blood - changes in platelet count

  • REFERENCE :

  • AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 152,861,1992

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - man

  • DOSE/DURATION :

  • 9713 mg/kg/58W-I

  • TOXIC EFFECTS :

  • Gastrointestinal - nausea or vomiting Skin and Appendages - sweating Nutritional and Gross Metabolic - metabolic acidosis

  • REFERENCE :

  • SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 84,496,1991

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 7 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,544,1982

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 730 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 5 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,544,1982

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 3500 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 38,241,1938

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 3720 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

  • REFERENCE :

  • OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,149,1973

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 358 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 3500 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 5 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,831,1971

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Unreported

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 4 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041937

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 4550 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - guinea pig

  • DOSE/DURATION :

  • 3500 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 38,241,1938 ** TUMORIGENIC DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 174 gm/kg/94W-C

  • TOXIC EFFECTS :

  • Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

  • REFERENCE :

  • ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 38,106,1981 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81908 No. of Facilities: 1815 (estimated) No. of Industries: 10 No. of Occupations: 19 No. of Employees: 13494 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81908 No. of Facilities: 3028 (estimated) No. of Industries: 15 No. of Occupations: 46 No. of Employees: 61057 (estimated) No. of Female Employees: 26152 (estimated)

 Safety Information

SymbolArticle illustration
GHS07
Signal WordWarning
Hazard StatementsH319
Precautionary StatementsP280-P305 + P351 + P338-P337 + P313
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Gloves
Hazard CodesXi:Irritant
Risk PhrasesR36/37/38
Safety PhrasesS26-S36
RIDADR2810.0
WGK Germany1
RTECSQS3675000
Hazard Class6.1
HS Code29362990

 Synthetic Route

Previous 1/75 Next
Article illustration

Nicotinyl alcoh...

100-55-0

~95%

Article illustration

Nicotinic acid

59-67-6

Literature: Mirza-Aghayan, Maryam; Molaee Tavana, Mahdieh; Boukherroub, Rabah Tetrahedron Letters, 2014 , vol. 55, # 2 p. 342 - 345
Article illustration

3-Mepy

108-99-6

~99%

Article illustration

Nicotinic acid

59-67-6

Literature: Jubilant Life Sciences Limited Patent: EP2428505 A2, 2012 ; Location in patent: Page/Page column 6-7 ;
Article illustration

Nicotinic acid ...

2398-81-4

~85%

Article illustration

Nicotinic acid

59-67-6

Literature: Ryzhakov, A. V.; Elaev, N. R. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 8 p. 859 - 861 Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 8 p. 1075 - 1076

 Precursor & DownStream

Precursor  9

Previous 1/3 Next

  • Article illustration CAS#:100-55-0
    Nicotinyl alcohol

  • Article illustration CAS#:108-99-6
    3-Mepy

  • Article illustration CAS#:2398-81-4
    Nicotinic acid ...

  • Article illustration CAS#:500-22-1
    Nicotinaldehyde

DownStream  10

Previous 1/3 Next

  • Article illustration CAS#:10354-56-0
    3-Pyridinecarbo...

  • Article illustration CAS#:109822-09-5
    3-(3-carbamoylp...

  • Article illustration CAS#:5006-66-6
    6-Hydroxynicoti...

  • Article illustration CAS#:609-71-2
    2-Hydroxy acid

 Customs

HS Code2933399090
Summary2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621








Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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