Product Details
| Product Name:
NG25 |
CAS No.:
1315355-93-1 |
| Purity:
≥95% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | NG25 |
| 描述 | NG25 is a potent dual inhibitor of TAK1 and MAP4K2, with IC50s of 149 nM and 21.7 nM, respectively. |
| 細(xì)胞實(shí)驗 | Breast cancer cells were seeded in 12-well plates at 2?×?10^3 cells per well, then incubated with Dox alone or Dox with NG25 at indicated concentrations after 72?h and then were cultured in fresh medium without drug.?Two weeks later, cells were fixed and stained with methanol/crystal violet for 10?min, and photographed.?Each experiment was performed in triplicates[1]. |
| 體外活性 | NG25 sensitizes the breast cancer cells to Dox treatment in vitro. This combination may be an effective and feasible therapeutic option maximizing Dox efficacy and meanwhile minimizing Dox side effects in treating breast cancer[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 16.67 mg/mL (31 mM), Sonication is recommended.
|
| 關(guān)鍵字 | NG-25 | NG 25 | NG25 | MAP kinase kinase kinase, MEKK, MAPKKK | MAP4K | inhibit | Inhibitor | MAP3K | MAPK Kinase Kinase Kinase |
| 相關(guān)產(chǎn)品 | Sodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | GNE-1858 | Takinib | MK2-IN-3 hydrate | Selonsertib |
| 相關(guān)庫 | 細(xì)胞凋亡化合物庫 | 神經(jīng)再生化合物庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 激酶抑制劑庫 | 抑制劑庫 | 干細(xì)胞分化化合物庫 | 已知活性化合物庫 | 細(xì)胞骨架化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1670.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States