Neuropeptide W-23(human) NEW
| Price | $123 | $372 | $538 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: Neuropeptide W-23(human) | CAS No.: 383415-79-0 |
| Purity: 98.5% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | Neuropeptide W-23(human) |
| 描述 | Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2. |
| 體外活性 | NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7 which may involve in the development of vascular hypertension. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1]. |
| 體內(nèi)活性 | NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124 which suggests that orexin neurons are downstream targets of NPW [2]. |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : Soluble |
| 關(guān)鍵字 | Neuropeptide W23(human) | Neuropeptide W-23 | hypetension | anorexigenic effect | Neuropeptide W 23(human) | Neuropeptide W-23 (human) | NPW23 | GPR7 | Inhibitor | Neuropeptide W | GPR8 | NPBW1 | NPBW2 | NPW 23 | inhibit |
| 相關(guān)庫 | 多肽分子庫 | NO PAINS 化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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