Netarsudil Dihydrochloride NEW
| Price | $50 | $60 | $78 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Netarsudil Dihydrochloride | CAS No.: 1253952-02-1 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Netarsudil Dihydrochloride |
| 描述 | Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP). |
| 體外活性 | METHODS: Primary PTM cells were incubated for 6 hours in the presence of 0, 0.015, 0.138 or 1.2 μM Netarsudil, then fixed and stained with Alexa Fluor-488 phalloidin and Hoechst 33342, Netarsudil dosage in actin stress fiber assay reaction. RESULTS Netarsudil's ability to disrupt actin stress fibers and focal adhesions in PTM cells and HTM cells. [1] METHODS: Serum-starved primary HTM cells were incubated for 24 hours in the presence of either vehicle, fixed and stained for fibrosis markers with 8 ng/mL human TGF-β2, 500 nM netarsudil or 8 ng/mL TGF-β2 plus 500 nM netarsudil. α-SMA, fibroblast-specific protein 1 (FSP1) and collagen 1A were used to explore the effect of Netarsudil on the profibrotic effect of TGF-β on HTM cells. RESULTS Simultaneous treatment of HTM cells with TGF-β2 and Netarsudil abolished the induction of these markers by TGF-β2, indicating that Netarsudil has antifibrotic activity. [1] |
| 體內(nèi)活性 | METHODS: Netarsudil 0.04% was administered once to one eye per animal for 3 days, with the untreated eye serving as a control. After dosing each morning on days 1 and 3, before test article administration (time 0) and at 1, 2, 4, 8 and 24 hours (rabbit) or 4, 8 and 24 hours (monkey) Intraocular pressure in both eyes. RESULTS Netarsudil 0.04% achieved greater IOP reduction and longer duration of efficacy. The greatest difference was seen 8 hours after dosing on Day 3, when Netarsudil 0.04% reduced IOP by 8.1 ± 0.7 mmHg. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (94.98 mM), Sonication is recommended. |
| 關鍵字 | Netarsudil Dihydrochloride | AR13324 Dihydrochloride | AR 13324 | Netarsudil | AR 13324 Dihydrochloride | AR-13324 | AR13324 |
| 相關產(chǎn)品 | SB-747651A Dihydrochloride | GSK180736A | SAR407899 hydrochloride | RKI-1447 | Belumosudil | Fasudil hydrochloride | Y-27632 dihydrochloride | Tofacitinib | Y-27632 | ROCK-IN-5 | Thiazovivin | CAY10746 |
| 相關庫 | 經(jīng)典已知活性庫 | EMA 上市藥物庫 | 激酶抑制劑庫 | 藥物功能重定位化合物庫 | 抗癌上市藥物庫 | FDA 上市激酶抑制劑庫 | FDA 上市藥物庫 | 已知活性化合物庫 | TGF-β/Smad靶點化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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