Naproxen sodium NEW
| Price | $34 |
| Package | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Naproxen sodium | CAS No.: 26159-34-2 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Naproxen sodium |
| Description | Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties. |
| Cell Research | Cells are exposed to Naproxen for 24 and 48 hours, respectively. At the end of incubation, cells are harvested by trypsinization, stained with trypan blue solution (0.04% wt/vol) and counted in a Neubauer haemocytometer chamber for the determination of cell viability.(Only for Reference) |
| Kinase Assay | COX-1 and COX-2 activities in intact cells: For the determination of COX-1 and COX-2 inhibition, bovine aortic endothelial cells (BAEC) are incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), and cultured J774.2 macrophages are treated with endotoxin at 1 μg/mL for 12 hours to induce COX-2 followed by incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), respectively. Arachidonic acid (30 μM) is then added, and the cells are incubated for a further 15 minutes at 37 °C. The medium is then removed, and radioimmunoassay is used to measure the formation of 6-keto-PGF1α, PGE2, thromboxane B2, or PGF2α for the assessment of IC50 for COX-1 and COX-2. |
| In vitro | In rat models of carrageenan-induced arthritis and attenuation of pain perception (IC50=27 μM) as well as yeast-induced fever (IC50=40 μM), Naproxen exhibits inhibitory effects. Additionally, in rats, Naproxen suppresses the production of PGE2 (IC50=12.8 μM) and TXB2 (IC50=5.9 μM) triggered by lipopolysaccharides. |
| In vivo | In HCA-7 colon cancer cells (IC50=1.45 mM), high concentrations of Naproxen induce apoptosis. Within cells, Naproxen inhibits COX-1 (IC50=2.2 μg/mL) and COX-2 (IC50=1.3 μg/mL). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 4.55 mg/mL (18.02 mM) H2O : 198.2 mM |
| Keywords | Autophagy | inhibit | RS 3650 | Naproxen | Cyclooxygenase | RS3650 | COX | Inhibitor | Naproxen sodium |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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