Naphthofluorescein NEW
| Price | $44 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Naphthofluorescein | CAS No.: 61419-02-1 |
| Purity: 99.34% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Naphthofluorescein |
| 描述 | Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging. |
| 體外活性 | Naphthofluorescein (compound 19) (0-10 μM; 24 h; HT1080 cells) significantly suppresses HIF-1 reporter activity in a concentration-dependent manner.[1] |
| 體內(nèi)活性 | Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily; 5 days followed by 2 days off for 2 weeks; Male C57BL/6J mice) significantly suppresses tumour growth in subcutaneous E0771 cells and attenuates tumour growth in MDA-MB-231 and AsPC-1 cells in immunodeficient mice. It inhibits tumour growth in human cancer cells in an FIH-1-dependent manner and does not affect FIH-1-depleted MDA-MB-231 cells. No weight loss, histological abnormalities in the lung, liver, and kidney, or severe adverse effects were observed in the mice for at least 2 weeks.[1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 2 mg/mL DMSO : 100 mg/mL (231.26 mM), Sonication is recommended. DMF : 10 mg/mL DMF:PBS (pH 7) (1:10) : 0.09 mg/mL |
| 關(guān)鍵字 | Naphthofluorescein |
| 相關(guān)產(chǎn)品 | Dapagliflozin | ZINC13466751 | DMOG | PT-2385 | Roxadustat | Hydroxycitric acid tripotassium hydrate | Oltipraz | Vadadustat | Acriflavine Hydrochloride | Cinnamaldehyde |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36?Washington?Street, Wellesley?Hills
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