N6-(2-Hydroxyethyl)adenosine NEW
| Price | $32 | $48 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: N6-(2-Hydroxyethyl)adenosine | CAS No.: 4338-48-1 |
| Purity: 99.4% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | N6-(2-Hydroxyethyl)adenosine |
| 描述 | N6-(2-Hydroxyethyl)adenosine, a Ca2+ antagonist and anti-inflammatory agent, is associated with the regulation of cerebral and coronary circulation and is believed to exhibit sedative activity. |
| 體外活性 | N6-(2-Hydroxyethyl)adenosine can suppress TGF-β1 or LPS-induced TGF-β1/Smad and NF-κB signaling pathways in vitro. The levels of ECM production, indicated by expression of collagen I, α-SMA and Fibronectin, are significantly reduced by treatment with N6-(2-Hydroxyethyl)adenosine dose-dependently (5, 10, and 20 μg/ml). Similarly, TGF-β and LPS stimulate increased levels of TNF-α, IL-1β and IL-10. N6-(2-Hydroxyethyl)adenosine treatment reduces the elevated levels of TNF-α and IL-1β and increases IL-10 secretion dose-dependently [1]. |
| 體內(nèi)活性 | Injury of Kidney Tissue in UUO Mice Ameliorated by Intraperitoneal Administration of N6-(2-Hydroxyethyl) adenosine (2.5, 5, and 7.5 mg/kg; intraperitoneal injection). N6-(2-Hydroxyethyl) adenosine treatment prevents the accumulation of fibrosis-related proteins (TGF-β1, α-SMA, collagen I, and Fibronectin) and inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-10) associated with renal interstitial fibrosis. N6-(2-Hydroxyethyl) adenosine could block the accumulation of M1 macrophages, and induced the accumulation of M2 macrophages in ligated kidneys [1]. |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 4.8 mg/mL (15.42 mM) |
| 相關(guān)產(chǎn)品 | Nisoldipine | Nimodipine | 2,5-Di-tert-butylhydroquinone | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Lanthanum(III) chloride heptahydrate | Ethyl cinnamate | 1-Octanol | Otilonium bromide |
| 相關(guān)庫(kù) | 疼痛相關(guān)化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 神經(jīng)信號(hào)分子庫(kù) | 膜蛋白靶向化合物庫(kù) | 神經(jīng)保護(hù)化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 離子通道庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $29.00/10mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-16 | |
| $0.00/100g |
Hefei Huana Biomedical Technology Co.,Ltd.
|
2023-05-11 | ||
| $1.00/1g |
VIP1Y
|
Apeloa production Co.,Limited
|
2024-06-03 | |
| $0.00/1kg |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-26 | |
| $5.00/5KG |
VIP7Y
|
Career Henan Chemical Co
|
2019-08-02 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY