N1-Methylpseudouridine NEW
| Price | $39 | $80 | $128 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-12 |
Product Details
| Product Name: N1-Methylpseudouridine | CAS No.: 13860-38-3 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/05/12 |
Product Introduction
Bioactivity
| Name | N1-Methylpseudouridine |
| Description | N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density in mRNA. |
| In vitro | In HEK293T cells, Incorporation of N1-Methylpseudouridine into mRNA modifies mRNAs produced higher amounts of luc than the standard Luc mRNA .?Incorporation of N1-Methylpseudouridine nucleoside modification in both Luc and GFP mRNA enhances the initiation step of translation, in part by suppressing eIF2α phosphorylation.?In addition, polysome formation and growth on the N1-Methylpseudouridine-containing Luc mRNA is enhanced due to the reduction of elongation rate[1]. |
| In vivo | mRNAs containing the N1-Methylpseudouridine modification alone and/or in combination with 5-methylcytidine (m5C) outperformed the current state-of-the-art pseudouridine (Ψ) and/or m5C/Ψ-modified mRNA platform by providing up to ~44-fold (when comparing double modified mRNAs) or ~13-fold (when comparing single modified mRNAs) higher reporter gene expression upon transfection into cell lines or mice, respectively. We show that (m5C/)N1-Methylpseudouridine-modified mRNA resulted in reduced intracellular innate immunogenicity and improved cellular viability compared to (m5C/)Ψ-modified mRNA upon in vitro transfection[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 40 mg/mL (154.9 mM), Sonication is recommended. DMSO : 100 mg/mL (387.25 mM), Sonication is recommended. |
| Keywords | ribosome | protein | polysomes | phosphorylation | Nucleoside Antimetabolite/Analog | N1-Methylpseudouridine | N-1-Methylpseudouridine | N1Methylpseudouridine | N1 Methylpseudouridine | mRNA | Inhibitor | inhibit | HEK293T | GFP | expression | eIF2α | DNA/RNA Synthesis | cells |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | Nucleotide Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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