N-acetylcysteine amide NEW
| Price | $39 | $64 | $97 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: N-acetylcysteine amide | CAS No.: 38520-57-9 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | N-acetylcysteine amide |
| 描述 | N-Acetylcysteine amide is a thiol antioxidant and a neuroprotective agent with cell permeability and blood-brain barrier permeability. N-Acetylcysteine amide reduces ROS production. |
| 細胞實驗 | To determine effectiveness of NACA and NAC in protection of H9c2 cells from DOX-induced toxicity, cells were treated with NACA or NAC at 0.75 mM for 2 h followed by exposure to freshly prepared cell culture medium with DOX in presence or absence of NACA or NAC at designated concentrations. The concentrations of DOX were 0.25 μM, 0.75 μM, 2 μM, 5 μM, 20 μM, and 100 μM. The exposure durations were 24 h, 48 h, or 48 h. Cells incubated with NACA or NAC alone were used as the control[1]. |
| 動物實驗 | rats were randomly divided into three groups (n=6-8 animals/group): N-acetylcysteine amide?loaded pump (18.5?mg/kg/hr) and a single 150 mg/kg bolus intraperitoneal (IP) injection of NACA given (30 min post-injury) ?N-acetylcysteine amide?(18.5 mg/kg/hr) loaded pump and a single 150 mg/kg bolus injection of N-acetylcysteine amide?given IP (30 min post-injury) ?Vehicle loaded pump and?single vehicle bolus injection given IP (30 min post-injury).?Following random distribution of all animals into one of the three previous groups, experimenters were blinded to treatment group.?The osmotic mini pumps were assembled and implanted immediately after injury and remained in the animals for 7 days[2] |
| 體外活性 | METHODS: Human esophageal cancer cells KYSE30 and KYSE150 were treated with LAT1-IN-1 (1-100 mM) for 3 days, and cell viability was measured by MTT assay. RESULTS: LAT1-IN-1 treatment inhibited cell proliferation in a dose-dependent manner. [1] METHODS: HTR8 SVneo, JEG-3 and JAR cells were treated with LAT1-IN-1 (0.1-4 μM) for 24 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: LAT1 protein was significantly reduced after 24 h LAT1-IN-1 treatment, and LAT1-IN-1 could directly regulate the expression of LAT1. [2] |
| 體內(nèi)活性 | METHODS: To assay antitumor activity in vivo, LAT1-IN-1 (200 mg/kg) was administered intravenously to BALB/c nude mice bearing KYSE150 tumors once daily for 14 days. RESULTS: Daily treatment with LAT1-IN-1 for 14 consecutive days significantly delayed tumor growth. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 100 mg/mL (616.48 mM), Sonication is recommended. DMSO : 55 mg/mL (339.07 mM) |
| 關(guān)鍵字 | Nacetylcysteine amide | N acetylcysteine amide | Reactive Oxygen Species | inhibit | N-Acetylcysteine amide | Inhibitor | N-acetylcysteine Amide |
| 相關(guān)產(chǎn)品 | Sodium Thiocyanate | L-Ascorbic acid | α-Vitamin E | Ammonium sulfate | Glucosamine | D-(+)-Glucono-1,5-lactone | Tempol | 3-Amino-1,2,4-triazole | Lycopene | Ethyl cinnamate | Coenzyme Q10 | Naringenin |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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