MS 15203 NEW
| Price | $38 | $60 | $106 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: MS 15203 | CAS No.: 73912-52-4 |
| Supply Ability: 10g | Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | MS 15203 |
| 描述 | MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice. |
| 體外活性 | To assess the selectivity of MS 15203 for GPR171, screened the ligand against a panel of 80 different transmembrane and soluble receptors, including ~70 GPCRs. MS 15203 dose-dependently displaced radiolabeled b-LEN from hypothalamic membranes with an affinity that was lower than that of b-LEN. IC50 = 80 ± 1 (nM). [1] |
| 體內(nèi)活性 | To examine the effects of long-term activation of GPR171, administered MS 15203 (2.5 mg/kg) to mice by intraperitoneal injection every third day and fed a high-fat diet to exacerbate the effects of the compound. Knockdown of GPR171 in the hypothalamus significantly at tenuated MS 15203-induced weight gain, implying that chronic administration of MS 15203 affects body weight through GPR171. [1] |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 40 mg/mL (160.50 mM), Sonication is recommended. |
| 關(guān)鍵字 | MS-15203 | MS15203 | MS 15203 |
| 相關(guān)產(chǎn)品 | Vincamine | Monomethyl fumarate | Questiomycin A | Azathioprine | CRTh2 antagonist 2 | Fezagepras sodium | Benzyl nicotinate | 1-methoxycyclopropanecarboxylic acid | TUG-1375 | CAY10595 | Timapiprant | NF-56-EJ40 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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