MRTX-1719 NEW
| Price | $398 | $778 | $1058 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: MRTX-1719 | CAS No.: 2630904-45-7 |
| Purity: 99.18% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | MRTX-1719 |
| 描述 | MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines. |
| 體外活性 | METHODS: To study the selectivity of MRTX1719 in reducing MTAP del tumor cell viability, 70 MTAP del and 26 MTAP WT human cancer cell lines were evaluated in a 5-day CellTiter-Glo (CTG) viability assay. RESULTS MRTX1719 selectively reduced the viability of MTAP del cell line, with minimal impact on MTAP WT cells. The median IC50 value of MRTX1719 in MTAP del cell line was 90 nmol/L, while the median IC50 value of MRTX1719 in MTAP WT cell line was IC50 is 2.2 μmol/L. [1] METHODS: MRTX1719 was studied in MTAP-del SDMA cells and MTAP-del active cell experiments. RESULTS IC50 = 8 nM in the MTAP-del SDMA experiment and IC50 = 12 nM in the MTAP-del activity experiment, with 82-fold and 74-fold selectivity over the corresponding MTAPWT experiment. [2] |
| 體內(nèi)活性 | METHODS: MRTX1719 was studied in selected MTAP del cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) models for ～3 weeks at 100 mg/kg orally. RESULTS MRTX1719 showed significant anti-tumor activity in all models tested. [1] METHODS: Lu-99 is a human lung cancer cell line lacking MTAP/cdkn2a. When tumors reached ~200 mm3, MRTX1719 was administered by gavage (12.5, 25, 50, and 100 mg/kg) once daily until day 21. Tumor volumes were measured throughout the study. RESULTS MRTX1719 can inhibit the growth of Lu-99 cells in a concentration-dependent manner. [2] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (107.55 mM) |
| 關(guān)鍵字 | CRC | MRTX 1719 | Histone Methyltransferase | MRTX-1719 | NSCLC | Inhibitor | MTA | MRTX1719 | inhibit | PRMT5 |
| 相關(guān)產(chǎn)品 | BIX-01294 trihydrochloride | Tazemetostat | Tazemetostat hydrobromide | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 |
| 相關(guān)庫(kù) | 組蛋白修飾化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 表觀遺傳庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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