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Postion:Product Catalog >MRT-83
MRT-83
  • MRT-83

MRT-83 NEW

Price $58 $93 $193
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: MRT-83 CAS No.: 1263131-92-5
Purity: 99.92% Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱MRT-83
描述MRT-83 is a potent Smo antagonist.
體外活性MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays[1].
體內(nèi)活性MRT-83 can't up-regulation of Ptc transcription in the SVZ of these animals in agreement with complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (102.12 mM), Sonication is recommended.
關(guān)鍵字MRT-83 | MRT83 | Inhibitor | MRT 83 | Smo | inhibit | Smoothened
相關(guān)產(chǎn)品IHR-1 | ALLO-2 | Purmorphamine | GI-560192 | LEQ506 | Halcinonide | BMS-833923 | Cyclopamine | Taladegib | SAG | MRT-14 | MK-4101
相關(guān)庫經(jīng)典已知活性庫 | 抑制劑庫 | 干細(xì)胞分化化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | Wnt/Hedgehog/Notch 通路化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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