MMAF-OMe NEW
Price | $34 | $52 | $82 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: MMAF-OMe | CAS No.: 863971-12-4 |
Purity: 99.34% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | MMAF-OMe |
Description | MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin. |
In vitro | 2.5F-Fc and 2.5F-Fc-MMAF exhibit similar IC50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively)[1], indicating that MMAF conjugation has a negligible impact on integrin-binding affinity[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | 5% DMSO+95% Saline : 4 mg/mL (5.36 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 99 mg/mL (132.70 mM) |
Keywords | ADC Payload | Inhibitor | inhibit | MMAF-OMe | MMAFOMe | MMAF OMe | ADC Cytotoxin |
Inhibitors Related | Methotrexate | Mertansine | Doxorubicin hydrochloride | Daunorubicin hydrochloride | Exatecan | Camptothecin | Dexamethasone acetate | Dexamethasone | Fluticasone (propionate) | Paclitaxel |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$40.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$0.00/5mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$0.00/1kg |
VIP2Y
|
Sichuan HongRi Pharma-Tech Co.,Ltd
|
2024-04-13 | |
$52.00/10mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY