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Postion:Product Catalog >MMAF-OMe
MMAF-OMe
  • MMAF-OMe

MMAF-OMe NEW

Price $34 $52 $82
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: MMAF-OMe CAS No.: 863971-12-4
Purity: 99.34% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMMAF-OMe
DescriptionMMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.
In vitro2.5F-Fc and 2.5F-Fc-MMAF exhibit similar IC50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively)[1], indicating that MMAF conjugation has a negligible impact on integrin-binding affinity[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information5% DMSO+95% Saline : 4 mg/mL (5.36 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 99 mg/mL (132.70 mM)
KeywordsADC Payload | Inhibitor | inhibit | MMAF-OMe | MMAFOMe | MMAF OMe | ADC Cytotoxin
Inhibitors RelatedMethotrexate | Mertansine | Doxorubicin hydrochloride | Daunorubicin hydrochloride | Exatecan | Camptothecin | Dexamethasone acetate | Dexamethasone | Fluticasone (propionate) | Paclitaxel

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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