Product Details
Product Name:
ML351 |
CAS No.:
847163-28-4 |
Purity:
97.67% |
Supply Ability:
10g |
Release date:
2024/11/11 |
Product Introduction
Bioactivity
名稱 | ML351 |
描述 | ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). |
體外活性 | ML351 exhibited nanomolar potency and excellent selectivity (>250-fold) versus 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. In mouse neuronal HT22 cells, ML351 dose-dependently protected against oxidative glutamate toxicity and completely reversed the increase in 12-HETE following glutamate treatment [2][3] |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 22.5 mg/mL (90.26 mM)
|
關(guān)鍵字 | Subarachnoid hemorrhage | ML-351 | inhibit | oxidative stress | SAH | ML351 | neuronal | Lipoxygenase | ML 351 | LOX | T1D | β-cell | Inhibitor | non-obese diabetic |
相關(guān)產(chǎn)品 | 2,5-Di-tert-butylhydroquinone | Caffeic Acid | 5-LOX inhibitor | Diethylcarbamazine citrate | Setileuton | Phenidone | Resveratrol | NNK | PF-4191834 | 5-Aminosalicylic Acid | Malotilate | KKII5 |
相關(guān)庫 | 鐵死亡化合物庫 | 經(jīng)典已知活性庫 | 抗肥胖化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 代謝化合物庫 | 脂代謝化合物庫 | 已知活性化合物庫 | 抗代謝疾病化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |