ML324 NEW
| Price | $47 | $72 | $130 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: ML324 | CAS No.: 1222800-79-4 |
| Purity: 98.22% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | ML324 |
| 描述 | ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). |
| 激酶實(shí)驗(yàn) | The fluorescence resonance energy transfer (FRET)-based LANCE Ultra KinaSelect Ser/Thr kit is used to determine IC50 values for various CDK inhibitors. Briefly, a specific ULight MBP peptide substrate (50 nM final concentration) is phosphorylated by a CDK-cyclin pair in buffer (50 mM HEPES-KOH pH 7.5, 10 mM MgCl2, 1 mM EGTA, 2 mM dithiothreitol) containing ATP at the concentration of the Km values of the individual kinases for 1 h at room temperature. Subsequently, phosphorylation is detected by addition of specific Eu-labelled anti-phospho-antibodies (2 nM), which upon binding to the phosphopeptide give rise to a FRET signal. FRET signals are then recorded[1]. |
| 體外活性 | ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression. [1] |
| 體內(nèi)活性 | In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation. [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 3 mg/mL (8.58 mM), Heating is recommended. DMSO : 40 mg/mL (114.5 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | Jumonji | periodontal | Cytomegalovirus | inhibit | simplex | CMV | Inhibitor | Herpes simplex virus | human | disease | HSV | H3K9 | herpes | ML 324 | virus | domain | immunity | periodontitis | inflammation | ML-324 | Histone Demethylase | containing | ML324 | proteins |
| 相關(guān)產(chǎn)品 | Isoborneol | Floxuridine | Docusate sodium | Octyl gallate | 1-Docosanol | Oxytetracycline Hydrochloride | 2-Deoxy-D-glucose | S-Methylisothiourea sulfate | Oxyresveratrol | Idoxuridine | Acyclovir | Ganciclovir |
| 相關(guān)庫 | 甲基化化合物庫 | 經(jīng)典已知活性庫 | 表觀遺傳庫 | 染色質(zhì)修飾分子庫 | 抗病毒庫 | 抑制劑庫 | NO PAINS 化合物庫 | 干細(xì)胞分化化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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