Product Details
| Product Name:
Mizagliflozin |
CAS No.:
666843-10-3 |
| Purity:
98.66% |
Supply Ability:
10g |
| Release date:
2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Mizagliflozin |
| 描述 | Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation. |
| 體內(nèi)活性 | METHODS: Mizagliflozin (GSK-1614235 free base) (0.3 mg/kg, intravenous administration) and oral administration (3 mg/kg, oral administration) were administered to rats to study its pharmacokinetics and metabolite profile.
RESULTS Mizagliflozin had different half-lives in rats (0.23 and 1.14 hours, respectively) depending on the administration route; the absolute bioavailability was only 0.02%; after oral administration, Mizagliflozin was mainly metabolized to its aglycone KP232 in the intestine. [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Methanol : 250 mg/mL (442.74 mM), Sonication is recommended.
DMSO : 100 mg/mL (177.09 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Chronic | GSK1614235 | DSP3235 | DSP-3235 | KGA3235 | selective | Sodium-dependent glucose cotransporters | constipation | DSP 3235 | antidiabetic | disorder | SGLT | Mizagliflozin | gastrointestinal | GSK 1614235 | inhibit | GSK-1614235 | KGA-3235 | Inhibitor | KGA 3235 |
| 相關(guān)產(chǎn)品 | Dapagliflozin ((2S)-1,2-propanediol, hydrate) | Ertugliflozin L-pyroglutamic acid | Dapagliflozin | Ipragliflozin | Sotagliflozin | Tofogliflozin (hydrate) | Phlorizin | Phloretin | Sergliflozin A | Empagliflozin | Canagliflozin | Ertugliflozin |
| 相關(guān)庫 | 糖代謝化合物庫 | 表型篩選靶點鑒定庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抗糖尿病庫 | 谷氨酰胺代謝化合物庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States