Mitoxantrone dihydrochloride NEW
| Price | $50 | $72 | $183 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Mitoxantrone dihydrochloride | CAS No.: 70476-82-3 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Mitoxantrone dihydrochloride |
| Description | Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. |
| Cell Research | The human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3]. |
| In vitro | In a murine air pouch model of inflammation, methotrexate demonstrated an inhibitory concentration 50 (IC50) of 0.08 mg/kg per week. |
| In vivo | Methotrexate inhibits the de novo synthesis of purines and pyrimidines, the formation of polyamines, and the transmethylation reactions of DNA, RNA, phospholipids, and proteins. It suppresses the enzyme thymidylate synthase, leading to a deficiency of thymidylate inside cells, which ultimately results in antiproliferative cytotoxicity. Methotrexate enters cells either through active transport or facilitated diffusion and, once inside, polyglutamation inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 38.8 mg/mL (75 mM) H2O : 2.6 mg/mL (5 mM) |
| Keywords | B-CLL cells | NSC 301739 | MCF-7 | Endogenous Metabolite | Orthopoxvirus | Inhibitor | Mitoxantrone dihydrochloride | breast cancer | Apoptosis | lymphocytes | leukaemia | mitozantrone | Topoisomerase | Protein kinase C | mitozantrone Dihydrochloride | NSC301739 | inhibit | Mitoxantrone Dihydrochloride | PKC | antitumor | Mitoxantrone | Mitozantrone | HL60 cells | Mitoxantrone Hydrochloride |
| Inhibitors Related | Berberine chloride | EIDD-1931 | Flumequine | Norfloxacin | α-Vitamin E | Prulifloxacin | Enoxacin | Ciprofloxacin | Ciprofloxacin monohydrochloride | Etoposide |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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