Product Name:    Metformin hydrochloride

Synonyms:    1,1-dimethyl-biguanidhydrochloride;diabefagos;diformin;dimethylbiguanidehydrochloride;Dimethyldiguanidinehydrochloride;GLUCOPHAGE;DIABETOSAN;DIABEX

CAS:    1115-70-4

MF:    C4H12ClN5

MW:    165.62

EINECS:    214-230-6

Product Categories:    API's;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Compounds;Aerobic Glycolysis (the Warburg Effect);Cancer Metabolism;Inhibitors and Activators of the AM PK pathway;Inhibitors of Aerobic Glycolysis (the Warburg Effect);Building Blocks;Cancer Research;Chemical Synthesis;Guanidines;FORTAMET;Inhibitors;Nitrogen Compounds;Organic Building Blocks;API;Diabetes Research;1115-70-4

Mol File:    1115-70-4.mol

Metformin hydrochloride is an oral hypoglycemic agent of the biguanide class, also known as metformin hydrochloride, gevalt and meticam, with a weaker hypoglycemic effect than phenelzine. Its main effect is to reduce the secretion of A-cell glucagon and promote the conversion of glucose into glycogen, with the property of not stimulating in sulin secretion by pancreatic beta-cells.

Metformin HCL CAS 1115-70-4 of Chemical Properties

Melting point     223-226 °C(lit.)

Fp     9oC

storage temp.     2-8°C

solubility     Freely soluble in water, slightly soluble in alcohol, practically insoluble in acet one and in methyl ene chlo ride

form     Powder

color     White

Water Solubility     Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).

λmax    233nm(H2O)(lit.)

Merck     14,5938

Stability:    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.

InChIKey    OETHQSJEHLVLGH-UHFFFAOYSA-N

CAS DataBase Reference    1115-70-4(CAS DataBase Reference)

Function and Application of Metformin HCL CAS 1115-70-4

1. Metformin hydrochloride may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations and human plasma samples by analytical techniques.

2. Metformin HCL use for Anti-diabetic and anti-cancer activity

3. Metformin HCL is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.