Meloxicam NEW
| Price | $33 | $83 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Meloxicam | CAS No.: 71125-38-7 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Meloxicam |
| Description | Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds. |
| In vitro | In horses, administration of Meloxicam significantly reduced lameness at both 8 and 24 hours post-injection and showed a tendency to decrease exudation. Compared to placebo, Meloxicam markedly inhibited the release of prostaglandin E2 and substance P in the synovial fluid 8 hours post-injection and reduced bradykinin release at 24 hours. Additionally, Meloxicam decreased average matrix metalloproteinase activity in the equine system at both 8 and 24 hours post-administration. Horses treated with Meloxicam or phenylbutazone showed improved postoperative pain and clinical outcomes compared to those treated with saline solution (SS). Meloxicam also induced a substantial infiltration of neutrophils in ischemic lesion tissues in horses. In dogs, Meloxicam significantly reduced concentrations of prostaglandin E2 in the blood and synovial fluid on days 7 and 21 post-administration, with no significant effect on thromboxane B2 (TXB2) levels in the blood or prostaglandin E2 (PGE2) concentrations in the gastric mucosa. Furthermore, Meloxicam inhibited tumor growth and pulmonary metastasis of LM-8 cells in mice. |
| In vivo | Meloxicam induces apoptosis in MG-63 cell cultures, concurrently upregulating both Bax mRNA and protein levels. It significantly reduces colony size in HCA-7 and Moser-S cells. While it markedly inhibits colony formation and tumor growth in HCA-7 cells, Meloxicam shows no effect on the growth of COX-2 negative HCT-116 cells. Furthermore, Meloxicam suppresses PGE(2) production, proliferation, and invasiveness, particularly in MG-63 cells expressing relatively higher levels of COX-2. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 12 mg/mL (34.15 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | COX | Apoptosis | Cyclooxygenase | Autophagy | Meloxicam |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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