Medroxyprogesterone Acetate NEW
| Price | $29 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Medroxyprogesterone Acetate | CAS No.: 71-58-9 |
| Purity: 99.45% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Medroxyprogesterone Acetate |
| Description | Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms. |
| In vitro | Medroxyprogesterone acetate (MPA) and progesterone significantly reduced the levels of glutamic acid decarboxylase (GAD) in the hippocampus, while markedly increasing GAD levels in the olfactory cortex. In aged ovariectomized rats, MPA impaired the retention of delayed memory in the swim arm task and exacerbated overnight forgetting in the Morris water maze. |
| In vivo | Medroxyprogesterone acetate (MPA) reduces the secretion of IL-6 and PTHrP in human breast cancer cells and downregulates their expression in KTC-2 cells in a dose-dependent manner. In M-1 cells, MPA and dexamethasone increase the promoter-driven luciferase activity of α-ENaC in a dose-dependent fashion, an effect which is not inhibited by Org31710, indicating that MPA's regulation of α-ENaC is independent of the progesterone receptor (PR). Similarly, MPA and dexamethasone upregulate the mRNA of α-ENaC and SGK1 in both M-1 and Madin-Darby canine kidney-C7 cells, whereas progesterone does not exhibit this effect. At 0.1 nM, MPA significantly enhances the in vitro production of specific immunoglobulin G antibodies, an effect that seems to involve the interaction between progesterone and the PRG receptor. MPA also inhibits the enzyme 3-hydroxysteroid dehydrogenase, which is involved in the reversible conversion between THP and DHP, thereby potentially affecting the action of DHP and THP in the brain. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 9 mg/mL (23.28 mM), Sonication is recommended. Ethanol : 10 mg/mL (25.87 mM), Sonication is recommended. |
| Keywords | progestogenReceptor | progestogen Receptor | ProgesteroneReceptor | Progesterone Receptor | PR | NSC26386 | NSC 26386 | NR3C3 | Medroxyprogesterone Acetate | Medroxyprogesterone | Inhibitor | inhibit | GlucocorticoidReceptor | Glucocorticoid Receptor | EstrogenReceptor | Estrogen Receptor | ER | EndogenousMetabolite | Endogenous Metabolite | AndrogenReceptor | Androgen Receptor |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Miao medicine Compound Library | Drug Repurposing Compound Library | Natural Product Library | FDA-Approved Drug Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | Bitter Compound library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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