MAO-B-IN-5 NEW
| Price | $155 | $385 | $548 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-21 |
Product Details
| Product Name: MAO-B-IN-5 | CAS No.: 849909-77-9 |
| Purity: 97.16% | Supply Ability: 10g |
| Release date: 2024/11/21 |
Product Introduction
Bioactivity
| Name | MAO-B-IN-5 |
| Description | MAO-B-IN-5 is a potent, selective, and orally active MAO-B inhibitor with an IC50 of 0.204 μM, showing potential for research in Parkinson's disease (PD) [1]. |
| In vitro | MAO-B-IN-5 (compound D0) exhibits inhibitory activity against MAO, with IC50 values of 34.190 μM for MAO-A and 0.204 μM for MAO-B in Sf9 cells [1]. |
| In vivo | MAO-B-IN-5 demonstrates oral bioavailability (F=13.6%) in rats when administered at doses of 1 mg/kg intravenously (i.v.) and 5 mg/kg orally (p.o.). The pharmacokinetic profile of MAO-B-IN-5 in Sprague-Dawley (SD) rats is detailed, with the compound showing a maximum concentration (Cmax) of 809 ng/mL and an area under the curve (AUC) of 347 ng·h/mL following a 1 mg/kg intravenous dose; the half-life (T1/2) is 0.37 hours, volume of steady state (Vss) is 1.11 h, and clearance (Cl) is 47.1 mL/min/kg. Orally administered at a dose of 5 mg/kg, MAO-B-IN-5 has a Cmax of 163 ng/mL, an AUC of 284 ng·h/mL, and a T1/2 of 1.27 hours, with an oral bioavailability of 16.3%. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | MAO B IN 5 | MAO-B-IN-5 | MAOBIN5 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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