Product Details
Product Name:
MAGL-IN-4 |
CAS No.:
2135785-20-3 |
Purity:
≥98% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | MAGL-IN-4 |
Description | MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases. |
In vitro | MAGL-IN-4 showed potent in vitro MAGL inhibitory activity (IC50 6.2 nM), good oral absorption and blood-brain barrier penetration[1]. |
In vivo | MAGL-IN-4 showed significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3-10 mg/kg, po. in mice[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 88 mg/mL (241.21 mM)
|
Keywords | Monoacylglycerol lipase | CB1 | lipase | monoacylglycerol | CB2 | Inhibitor | inhibit | BBB | barrier | MAGLIN4 | MAGL IN 4 | blood-brain | endocannabinoid | MAGL-IN-4 | hERG | FAAH | 2-AG | ABHD6 | MAGL |
Inhibitors Related | Atglistatin | WWL70 | KML29 | Y-320 | ABX-1431 | URB602 | JJKK 048 | AA38-3 | Endothelial lipase inhibitor-1 | XEN445 | NG-497 | Beta-Sitosterol |
Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Orally Active Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:304685-40-3
$30.00 / 2mg
-
CAS:1644156-56-8
$68.00 / 1mg
-
CAS:359714-55-9
$39.00 / 2mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$34.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
|
$3520.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
|
$0.00/1g |
VIP1Y
|
Wuhan Circle Star Chem-medical Technology Co.,Ltd
|
2025-01-17 |