m-3M3FBS NEW
| Price | $43 | $68 | $133 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: m-3M3FBS | CAS No.: 200933-14-8 |
| Purity: 99.92% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | m-3M3FBS |
| 描述 | m-3M3FBS is a phospholipase C (PLC) activator. |
| 體外活性 | m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?Moreover, m-3M3FBS stimulated the formation of inositol phosphates in U937 cells, indicating that it stimulates PLC activity.?The compound showed no cell-type specificity in terms of [Ca(2+)](i) increase in the various cell lines including leukocytes, fibroblasts, and neuronal cells,?also ruled out the possible involvement of heterotrimeric G proteins in m-3M3FBS-stimulated signaling by confirming the following: 1) pertussis toxin does not inhibit m-3M3FBS-induced [Ca(2+)](i) increase;?2) m-3M3FBS does not stimulate cyclic AMP generation;?and 3) the inhibition of G(q) by the regulator of G protein-signaling 2 does not affect the m-3M3FBS-induced [Ca(2+)](i) increase.?m-3M3FBS stimulated PLC activity in vitro.?The purified isoforms of PLC that were tested (i.e., beta2, beta3, gamma1, gamma2, and delta1) were activated by m-3M3FBS and showed no isoform specificity[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 4.4 mg/mL (12.81 mM) |
| 關(guān)鍵字 | calcium | superoxide | cells | THP-1 | phosphate | m 3M3FBS | Apoptosis | Inhibitor | m3M3FBS | Phospholipase | m-3M3FBS | leukemic | U937 | inositol | inhibit | neutrophils | m-3M-3FBS |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Stavudine | 5-Fluorouracil | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
| 相關(guān)庫(kù) | 細(xì)胞凋亡化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 血液病分子庫(kù) | 抗肥胖化合物庫(kù) | NO PAINS 化合物庫(kù) | 脂代謝化合物庫(kù) | 代謝化合物庫(kù) | 已知活性化合物庫(kù) | 抗代謝疾病化合物庫(kù) | Wnt/Hedgehog/Notch 通路化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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