Losartan NEW
| Price | $50 |
| Package | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Losartan | CAS No.: 114798-26-4 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Losartan |
| 描述 | Losartan (DuP-753) is an angiotensin II receptor antagonist. |
| 細(xì)胞實(shí)驗(yàn) | An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival. |
| 體外活性 | Losartan competes with the binding of angiotensin II to AT1 receptors, with an IC50 of 20 nM[1]. At 40 μM, losartan affects ISC and prevents the effect of ANGII on ISC[2]. It significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells, with a greater antiproliferative effect when combined with anti-miR-155 compared to each drug alone[3]. |
| 體內(nèi)活性 | Losartan (0.6 g/L, p.o.)-treated Fbn1C1039 g/+ mice show reduced distal airspace caliber compared to placebo-treated counterparts. The dosages of losartan and propranolol are titrated to achieve similar hemodynamic effects. Analysis of pSmad2 nuclear staining indicates that losartan antagonizes TGF-β signaling in the aortic wall of Fbn1C1039 g/+ mice, improving lung disease manifestations independently of hemodynamics[4]. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels by four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels by 100-fold, decreases plasma angiotensinogen levels to 24% of control, and leaves plasma aldosterone levels unchanged[5]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (106.41 mM) |
| 關(guān)鍵字 | DuP 753 | Angiotensin Receptor | DuP753 | Losartan | inhibit | Inhibitor |
| 相關(guān)產(chǎn)品 | Olmesartan Medoxomil | Tranilast | Enalapril Maleate | Azilsartan Methyl Ester | Sacubitril/Valsartan | Azilsartan | Irbesartan | Ramipril | Captopril | Valsartan Methyl Ester |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | FDA 上市藥物庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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